Virus Entry: Looking Back and Moving Forward
Identifieur interne : 000697 ( new/Analysis ); précédent : 000696; suivant : 000698Virus Entry: Looking Back and Moving Forward
Auteurs : Ari HeleniusSource :
- Journal of Molecular Biology [ 0022-2836 ] ; 2018.
Abstract
Research over a period of more than half a century has provided a reasonably accurate picture of mechanisms involved in animal virus entry into their host cells. Successive steps in entry include binding to receptors, endocytosis, passage through one or more membranes, targeting to specific sites within the cell, and uncoating of the genome. For some viruses, the molecular interactions are known in great detail. However, as more viruses are analyzed, and as the focus shifts from tissue culture to
Url:
DOI: 10.1016/j.jmb.2018.03.034
PubMed: 29709571
PubMed Central: 7094621
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000B11
- to stream Pmc, to step Curation: 000B11
- to stream Pmc, to step Checkpoint: 000284
- to stream Ncbi, to step Merge: 000781
- to stream Ncbi, to step Curation: 000781
- to stream Ncbi, to step Checkpoint: 000781
- to stream Main, to step Merge: 000D78
- to stream Main, to step Curation: 000D76
- to stream Main, to step Exploration: 000D76
- to stream new, to step Extraction: 000697
Links to Exploration step
PMC:7094621Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Virus Entry: Looking Back and Moving Forward</title><author><name sortKey="Helenius, Ari" sort="Helenius, Ari" uniqKey="Helenius A" first="Ari" last="Helenius">Ari Helenius</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">29709571</idno><idno type="pmc">7094621</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094621</idno><idno type="RBID">PMC:7094621</idno><idno type="doi">10.1016/j.jmb.2018.03.034</idno><date when="2018">2018</date><idno type="wicri:Area/Pmc/Corpus">000B11</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B11</idno><idno type="wicri:Area/Pmc/Curation">000B11</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000B11</idno><idno type="wicri:Area/Pmc/Checkpoint">000284</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000284</idno><idno type="wicri:Area/Ncbi/Merge">000781</idno><idno type="wicri:Area/Ncbi/Curation">000781</idno><idno type="wicri:Area/Ncbi/Checkpoint">000781</idno><idno type="wicri:doubleKey">0022-2836:2018:Helenius A:virus:entry:looking</idno><idno type="wicri:Area/Main/Merge">000D78</idno><idno type="wicri:Area/Main/Curation">000D76</idno><idno type="wicri:Area/Main/Exploration">000D76</idno><idno type="wicri:Area/new/Extraction">000697</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Virus Entry: Looking Back and Moving Forward</title><author><name sortKey="Helenius, Ari" sort="Helenius, Ari" uniqKey="Helenius A" first="Ari" last="Helenius">Ari Helenius</name></author></analytic><series><title level="j">Journal of Molecular Biology</title><idno type="ISSN">0022-2836</idno><idno type="eISSN">1089-8638</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Research over a period of more than half a century has provided a reasonably accurate picture of mechanisms involved in animal virus entry into their host cells. Successive steps in entry include binding to receptors, endocytosis, passage through one or more membranes, targeting to specific sites within the cell, and uncoating of the genome. For some viruses, the molecular interactions are known in great detail. However, as more viruses are analyzed, and as the focus shifts from tissue culture to <italic>in vivo</italic> experiments, it is evident that viruses display considerable redundancy and flexibility in receptor usage, endocytic mechanism, location of penetration, and uncoating mechanism. For many viruses, the picture is still elusive because the interactions that they engage in rely on sophisticated adaptation to complex cellular functions and defense mechanisms.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lonberg Holm, K" uniqKey="Lonberg Holm K">K. Lonberg-Holm</name></author><author><name sortKey="Philipson, L" uniqKey="Philipson L">L. 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